Our multidisciplinary work lies at the interface of molecular biology, biophysics, micro-engineering and nano-biotechnology. We combine fundamental and applied research, with technological innovation being a central focus. One main aspect of our work is the use of acoustic biosensors to study the structure of biomolecules and their significance in biological processes. Biophysical results are translated into the development of molecular diagnostic assays combined with isothermal amplification methods. Moreover, we couple the above assays with simple lab-fabricated 3D-printed prototypes or lab-on-chip platforms to create portable, low-cost systems for rapid genetic analysis. This work has resulted in innovations currently exploited to provide simple tools for molecular diagnostics anywhere in the world. We are now applying these technologies to address an expanding range of pertinent issues within the “One-Health” concept, including monitoring of human, plant and food-borne diseases as well as marine environmental monitoring. All our assays and measuring units are implemented in both the developed and developing countries where we continuously collaborate with end-users for testing (S. Africa, Mozambique, UK, France and Belgium).